Title: Associate Professor
Email: hshrkw@ PC (Please replace PC with pc.uec.ac.jp)
Phone: +81-42-443-5435
Office: East-6 Bldg. 728
Web: http://rainbow.pc.uec.ac.jp/ (in Japanese)
2002-2005, Assistant Professor, Tokyo Women's Medical University School of Medicine
1991-2002, Instructor, Tokyo Women's Medical University School of Medicine
Ph.D. 1997, Tokyo Women's Medical University
M.S. 1991, Graduate School of Science, The University of Tokyo
B.S. 1989, College of Biological Sciences, University of Tsukuba
Cell Physiology, Bioimaging
Intracellular calcium ion is an important factor that regulates a variety of cellular activities. Many types of cells respond to stimuli with the increase in the intracellular calcium concentration, and occasionally show wave-like spatial spread over the cytoplasm (calcium wave) and//or long-lasting repetitive increases (calcium oscillations). One of the goals of our research is the comprehensive understanding of the mechanism that underlying these interesting calcium dynamics, in terms of relations and interactions among many regulatory factors.
Molecular fluorescence is widely used for investigating dynamic biological phenomena in living cells and tissues. By using fluorescent probes with different spectra, we can monitor multiple species of molecules simultaneously, and thus can investigate their relations and interactions in the cells. We are developing the spectral imaging system to analyze spatial and temporal changes of many fluorescent components, either intrinsic or extrinsic, at once in single cells.